- Sequence the person's (healthy) genome
- Do a biopsy and sequence the cancerous mutation
- Find the {edit:] shortest sequence in the cancer that isn't in the genome
- Develop a broken, homing mega-endonuclease to locate it
2010-01-22
More Specifically
Referring to the last post
2010-01-17
Broken Homing Endonuclease Cancer Cures
Homing Endonuclease seeks out certain sequences in DNA and cleaves it at that point. Normally a ligase would simply find the two cleaved ends and fuse them together with some small ATP cost. However, if the enzymatic functioning was broken, leaving one cleaved end difficult or impossible to rejoin to the other, the endonuclease could impair or kill the host cell. While typically only short sequences of base pairs are recognized (as few as 6 base pairs in restriction modification systems in bacteria), mega-endonucleases which recognized far larger sequences might be developed to operate only sequences of base pairs associated with the patient's cancer.
If perfect, only recognizing the cancerous cells, inundation of the patient with the broken homing endonuclease could be sufficient, but delivery via virus is certainly also a possibility.
If perfect, only recognizing the cancerous cells, inundation of the patient with the broken homing endonuclease could be sufficient, but delivery via virus is certainly also a possibility.
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